What is a 'gold standard'?
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The term 'gold standard' can be referred to a test or a method. A test which shows the true status of the patient is termed gold standard. These test are assumed to have 100% sensitivity and specificity. Diagnostic power of other tests are evaluated based on the comparison with the gold standard test.When the term applies to a method or a procedure, a 'gold standard' serves as a basis for evaluation
of other methods.
Gold standard method for estimating resting energy expenditure - indirect calorimetry
Gold standard investigation for diagnosis of Iron deficiency anemia – Estimation of serum Ferritin
Gold standard for proving that the life span of red cell is decreased ( useful in Hemolytic anemia) - Red cell survival study
Gold standard for evaluation of stem cell transplantation therapy - Hemopoietic stem cell transplantation
Gold standard technique for differentiating allograft rejection and reactivation of disease after heart transplantation - Endo-myocardial Biopsy
Gold standard investigation for diagnosis of DVT - Contrast Venography
Gold standard investigation for diagnosis of acute pharyngitis - Throat Culture
Gold standard investigation for diagnosis of pertussis - Culture of nasopharyngeal secretions
Gold standard investigation for diagnosis of Otitis externa caused by P. aeruginosa - Technetium99 bone scan
Gold standard investigation for diagnosis of Acoustic Neuroma – Gadolinium MRI
Gold standard investigation for diagnosis of Shigella infection - Isolation and identification of pathogen from fecal material
Gold standard investigation for diagnosis of Tuberculous meningitis - Culture of CSF
Gold standard investigation for diagnosis of HSV Encephalitis - Brain biopsy (CSF PCR largely replaced brain biopsy in recent times)
Gold standard investigation for diagnosis of histoplasmosis - Fungal Culture
Gold standard investigation for diagnosis of hypertrophic cardiomypathy and atrial myxoma - Echocardiogram
Gold standard investigation for imaging heart valves and valve motion abnormalities - 2D echocardiography
Gold standard investigation for assessment of Myocardial viability (Identification of ischemic or hibernating myocardium)– PET
Gold standard investigation for assessment of LV mass and volume - MRI
Gold standard method for evaluation of renal arteries and identification of renal artery lesions - Contrast arteriography
Gold standard method for evaluation of respiratory gas exchange - ABG
Gold standard investigation for assessment of albuminuria - 24 hr urine collection
Gold standard investigation for diagnosis of PNH (Paroxysmal Nocturnal Haemoglobinuria) – Flow cytometry
Gold standard investigation for diagnosis of ATTR and other AF mutations - DNA sequencing
Gold standard method for identifying and quantifying atherosclerosis in cerebral arteries - X-ray cerebral angiography
Gold standard investigation for evaluating anatomy of arterio-venous malformation - X-ray angiography
Gold standard for diagnosis and classification of ataxia - genotype
Gold standard investigation for diagnosis of of lung infection (Radiotherapy induced) in a cancer patient - open-lung biopsy
Gold standard medical treatment for symptomatic progressive pulmonary hypertension – Prostacyclin
Gold standard investigation for diagnosis of PIH – Serum Urea
Gold standard for assessment of visual impairment - Snellen's chart
Gold standard method of treatment of non-castrate metastatic disease - surgical orchidectomy
Gold standard method for bacterial stain analysis - Pulse-field gel electrophoresis
Gold standard method of treatment of DCIS - Mastectomy
Gold standard approach for resection of anterior and middle mediastinal masses - median or lateral thoracotomy
Gold standard method of treatment of Coarctation of aorta - Surgical repair
Gold standard method for evaluation of coronary artery disease - Cardiac Catheterization
Gold standard method for culture of V. cholerae o139 - Conventional culture method
Gold standard to determine cut-off titer of widal test for diagnosis of Typhoid fever – Nested PCR
Gold standard treatment of brucellosis in adults - IM Streptomycin + Doxycyclin
Gold standard investigation for diagnosis of of chronic arterial mesentric ischemia - Angiography
Gold standard method for treatment of chronic ulcerative colitis - Total proctocolostomy with end ileostomy
Gold standard method for evaluation of imaging modalities for liver tumors - Intraoperative ultrasonography
Gold standard investigation for diagnosis of common bile duct stones - Endoscopic cholangiography
Gold standard investigation for measurement of GFR - Inulin clearance
Gold standard for treatment of organ confined, muscle invasive, bladder cancer is - Radical cystoprostatectomy in men and anterior pelvic exenteration in woman
Gold standard for treatment of femoral shaft fractures - Reamed locked intramedullary nailing
Gold standard method in case of difficult intubation - Flexible fibreoptic intubation scope
Gold standard method for diagnosis and treatment of Ventilator Associated Pneumonia (VAP) - Broncho alveolar lavage
Gold standard treatment of hyperparathyroidism - Surgery
Gold standard investigation to differentiate follicular and papillary carcinoma of thyroid gland- Histology
Gold standard procedure for thymectomy - Trans cervical mediastinoscopy and surgery
Gold standard for treatment of adrenal tumors - Laparoscopic adrenalectomy
Gold standard investigation for diagnosis of breast cancer - Mammography
Gold standard method for staging of breast cancer - Axillary lymph node dissection
Gold standard for evaluation of a stable patient with suspected vascular injury - Angiography
Gold standard investigation for diagnosis of GERD - Ambulatory 24 hr PH monitoring
Gold standard method for treatment of GERD - Laparoccopic Nissens fundoplication
Gold standard for evaluating cure rate in duodenal ulcer patients – Vagotomy
Gold standard finding for the diagnosis of GI perforation - Finding pneumoperitoneum
Gold standard for diagnosis of Zollinger-Ellison syndrome - Serum gastrin levels( Most patients have serum gastrin levels above 1000pg/mL)
Gold standard investigation for diagnosis of colonic mucosal disease - Colonoscopy
Gold standard investigation for diagnosis of steatorrhoea - Timed quantitative stool fat determination
Gold standard method for treatment of incontinence with an isolated sphincter defect - Overlapping sphincteroplasty
Gold standard investigation for diagnosis and method of management of Acute arterial occlusion – Laparotomy
Gold standard method for confirmation of mesentric arterial occlusion - Mesentric angiography
Gold standard investigation for diagnosis of celiac disease – Small intestine biopsy
Gold standard for identifying choledocholithiasis – ERCP
Gold standard method of treatment of Symptomatic cholelitiasis – Lap cholecystectomy
Gold standard method for diagnosis of Primary sclerosing cholangitis - ERCP
Gold standard investigation for diagnosis of Hepatitis C – HCV RNA assay
Gold standard test for diagnosis of intraluminal bile duct abnormalities - ERCP
Gold standard method for management of hydatid disease – Surgery
Gold standard for assessing degree of liver injury and fibrosis - Liver Biopsy
Gold standard method for management of blunt hepatic trauma - Non-operative management
Gold standard test for assessment of function of sphincter of oddi – Manometry
Gold standard investigation of diagnosis of Klatskin tumor - Cholangiography
Gold standard investigation for diagnosis of invasive amoebiasis - ELISA
REFERENCES
1. Harrison's principles of Internal Medicine 17th Edition
2. Schwartz's Manual of Surgery 8th Edition
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